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The 1st International Symposium

The First Global COE International Symposium on “Challenge to Medical Innovation” (December 7th and 8th, 2009, at Gonryo hall, Sendai)

We held the 1st International Symposium on “Challenge to Medical Innovation” on December 7th and 8th, 2009, at Gonryo hall.
The aim of this meeting is to activate interdisciplinary communications among cell growth, cell signaling, immunology, metabolism, cancer, stem cell research and medical applications, and to inspire young scientists who are participating in this program.
Top-flight researchers both from domestic and overseas was invited as guest speakers.

Symposuim Program

Opening Remark

Yoshitomo Oka(Tohoku University)


Session 1: Networks in Metabolic Regulation and Diseases

Hideki Katagiri
 (Tohoku University)
Obesity induces pancreatic β cell proliferation with neuronal network originating in the liver
Peter Tontonoz
 (University of California, USA)
Control of lipid metabolism by nuclear receptors

Session 2: Networks in Metabolic Regulation and Diseases

Takefumi Mori
 (Tohoku University)
Role of carbonyl stress on the pathogenesis of CKD, CVD and metabolic syndrome
Satoru Takahashi
 (University of Tsukuba)
Role of large Maf transcription factors in development and function of pancreatic and cells in vivo
Yo-ichi Nabeshima
 (Kyoto University)
Klotho and FGF19 subfamily; newly discovered metabolic regulators

Session 3: Molecular Networks in Cancer

Masayuki Yamamoto
 (Tohoku University)
The Nrf2-Keap1 system and cancer
Keiko Nakayama
 (Tohoku University)
Differential tissue specificity of ubiquitin ligase SCFFbxw7
Testuya Terasaki
 (Tohoku University)
Quantitative targeted absolute proteomics (QTAP) for the tumor drug resistance
Paul-Henri Roméo
 (The Institute of Cellular and Molecular Radiobiology,France)
Deciphering the molecular mechanisms of human T-cell acute lymphoblastic leukemia (T-ALL): from basic research to new targets for T-ALL treatment

Session 4: Molecular Networks in Cell Communication

Kinichi Nakashima
 (Nara Institute of Science and Technology)
Mechanism in sequential differentiation of neural stem cells mediated by neuron - stem cell interaction
Naoto Ishii
 (Tohoku University)
Roles of OX40 signals in the generation and maintenance of memory T cells
Takahiro Arima
 (Tohoku University)
Genome-wide screening of imprinted genes by meDIP-on-chip
Toshiyuki Takai
 (Tohoku University)
A novel regulatory system for TLR9 and autoimmunity mediated by PIR-B in B-1 cells

Session 5: Gene Regulatory Networks and Epigenetics

Harinder Singh
 (The University of Chicago, USA)
Gene regulatory networks and chromatin dynamics orchestrating innate and adaptive immune cell fates
Kazuhiko Igarashi
 (Tohoku University)
Decoding B cell responses based on gene regulatory networks
Hirofumi Kurokawa
 (Tohoku University)
Structural basis of alternative DNA recognition by Maf transcription factors
Toru Nakano
 (Osaka University)
Epigenetic gene regulation by GATA transcription factors

Session 6: Molecular Networks in Adipocyte Differentiation

James K. Liao
 (Brigham & Women's Hospital and Harvard Medical School,USA)
Altered Basal Metabolism and Increased Obesity in Mice with Targeted Deletion of Rho-associated Coiled-coil Forming Kinase (ROCK)-2
Masashi Okamura
 (Tohoku University)
The Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor α Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

Session 7: Molecular Networks in Cardiovascular Systems

Hiroaki Shimokawa
 (Tohoku University)
Important roles of endothelium-derived reactive oxygen species in cardiovascular and metabolic regulation
Yasufumi Sato
 (Tohoku University)
A novel intrinsic system for vascular stress tolerance
Toshio Miyata
 (Tohoku University)
Development of novel therapeutic agents for the treatment of renal cardiovascular diseases: inhibitors of plasminogen inhibitor 1 and oxygen sensor prolylhydroxylase

Session 8: Stem Cell Systems

Mari Dezawa
 (Tohoku University)
Bone Marrow-derived mesenchymal stem cells; A hope for auto-cell transplantation therapy for neuro- and muscle-degenerative diseases
Antonio Uccelli
 (University of Genoa, Italy)
Therapeutic plasticity of mesenchymal stem cells
Derek van der Kooy
 (University of Toronto, Canada)
Adult human retinal stem cells and the potential for treating blindness
Alan Mackay-Sim
 (National Centre for Adult Stem Cell Research, Griffith University, Australia)
Pluripotent adult stem cell from olfactory mucosa

Concluding Remark

Kazuhiko Igarashi(Tohoku University)


Poster Program

There were 39 poster presentations that were mainly provided by graduate students.

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Photo Report

Selected photos conveying enthusiastic presentations and discussion in the symposium.

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