Setsuya Aiba, MD, PhD

Naoto Ishii

Professor, Division of Microbiology and Immunology
Tohoku University Graduate School of Medicine

Education and Career

  • M.D., Ph.D.: Tohoku University School of Medicine, 1995
  • Assistant Professor, Tohoku University School of Medicine, 1996
  • Associate Professor, Tohoku University School of Medicine, 2003
  • Present, 2009-

Research Project

  • The immune system has been evolved for protective mechanisms against a variety of infectious pathogens. The dysregulation of immune signals, however, causes immune disorders including allergy, autoimmune diseases, inflammatory diseases, and immunodeficiency. Over the past 10 years, we have investigated the roles of OX40/OX40 ligand, a T cell costimulatory system, in T cell memory and T cell-mediated inflammation. We have demonstrated the pathogenic mechanisms mediated by OX40 signals for autoimmunity and inflammatory bowel disease, and proposed a new therapeutic strategy for these diseases by targeting OX40 ligand. In another project, we have established NOD/Shi-scid-IL-2Rgamma(gamma-c)null(NOG) mice, into which almost all of human cells and tissues can be transplanted because of the lack of any rejection responses in NOG mice. By using NOG mice, we are establishing a novel animal model in which the human immune system can be almost reconstituted, and attempting to identify cancer stem cells, including leukemia cells.


  • ishiin[atmark]


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