Professor, Division of Molecular Immunology, Institute of Development, Aging and Cancer
Education and Career
MD, Tohoku University Graduate School of Medicine, 1970
Assistant Professor, Kyoto University, Institute for Virus Research, 1984
Associate Professor, Kyoto University, Institute for Virus Research, 1988
Professor, Tohoku University, Institute of Development, Aging and Cancer, 1993
Research Project
Growth factor receptors and/or antigen receptors are once endocytosed from the plasma membrane when they receive signals from ligands. We are investigating how this vesicle-mediated incorporation of receptors is transformed into the signal transduction system in the cytoplasm and eventually transmitted to the gene regulatory complex in the nucleus. Molecular probes we employ include transferin receptor, T cell antigen receptor, ArfGTPase activating protein and Runx transcription factor, whereas cell types we examine correspond to myelocytes and T lymphocytes. We have established many gene-engineered mice most of which carry abnormalities in cell growth, differentiation, and apoptosis, and display pathological phenotypes such as cancer and immune diseases. In the present GCOE, we will reveal the network that link the molecular machinery inside the cells and the pleiotropic manifestation of human diseases such as MDS (myelodysplastic syndrome), leukemia, lymphoma and immunological disorders.
