Yoshiaki Ito, MD, PhD

Yoshiaki Ito

Deputy Director, Cancer Science Institute Singapore, National University of Singapore (NUS),
Adjunct: Yong Loo Lin Professor of Medical Oncology, Yong Loo Lin School of Medicine, NUS

Education and Career

1968 MD PhD, Tohoku University Graduate School of Medical Sciences
1969 Research Associate, Department of Microbiology and Immunology Duke University Medical Center, NorthCarolina, USA
1975 Scientifi c Staff , Department of Cell Regulation Imperial Cancer Research Fund Laboratories, London, England
1984 Professor, Laboratory of Cell Regulation, Department of Viral Oncology Institute for Virus Research, KyotoUniversity, Kyoto, Japan
  (1995-2001 Director, Institute for Virus Research, Kyoto University, Kyoto, Japan)
2002 Principal Investigator, Professor, Institute of Molecular and Cell Biology Director, Oncology Research Institute, NUS
2008- Deputy Director, Cancer Science Institute of Singapore, NUS
  Adjunct Professor, Institute of Molecular and Cell Biology
  Yong Loo Lin Professor of Medical Oncology, Department of Medicine, Yong Loo Lin School of Medicine, NUS


  • I am Director of Oncology Research Institute, National University of Singapore. I will be Deputy Director of Cancer Research Center of Excellence that is to be set up in National University of Singapore on 15 October, 2008 with total budget of S $172 million for 7 years. Together with Director, I will be responsible for recruiting members of CRCE, developing programs, establishing working relationship with School of Medicine and Hospitals, as well as for research collaboration with other universities and research institutes in Singapore and abroad. My personal research interest is molecular mechanisms of carcinogenesis with particular emphasis on RUNX genes. We found RUNX1 is guardian of hematopoietic stem cells. RUNX3 is involved in many cancers as a tumor suppressor and recently we found that RUNX3 is attenuator of Wnt signaling. I plan to establish collaborations with researchers in GCOE members, many of whom I know quite well. In addition, I will be a liaison person to link GCOE members to various branches within Singapore, especially, to Singapore Institute of Clinical Science, headed by Prof Judith Swain, who is specialized in metabolic diseases.


  1. Ito K, Lim AC, Salto-Tellez M, Motoda L, Osato M, Chuang LS, Lee CW, Voon DC, Koo JK, Wang H, Fukamachi H, Ito Y. RUNX3 Attenuates beta-Catenin/T Cell Factors in Intestinal Tumorigenesis. Cancer Cell. 14(3): 226-37 (2008).
  2. Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H, Huang C, Shah N, Inoue M, Rajnakova A, Hiong KC, Peh BK, Han HC, Ito T, Teh M, Yeoh KG, Ito Y. RUNX3, a novel tumor suppressor, is highly inactivated in gastric cancer by protein mislocalization. Cancer Res. 65(17): 7743-50 (2005).
  3. Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y, Littman DR. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell. 111(5): 621-33 (2002 ).
  4. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC, Ito Y. Casual Relationship between the Loss of RUNX3 Expression and Gastric Cancer. Cell. 109(1): 113-24 (2002).
  5. Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T, Kawaguchi S, Ogawa M, Bae SC, Yamashita N, Itohara S, Kudo N, Ito Y. RUNX 3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nat Neurosci. 5(10): 946-54 (2002).


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