Toshiyuki Takai, PhD width=

Toshiyuki Takai

Professor, Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University

Education and Career

  • Ph.D. (Kyoto University), 1986
  • Researcher, National Cardiovascular Center Research Institute, 1986
  • Assistant Professor, Okayama University Faculty of Engineering, 1988
  • Associate Professor, Okayama University, 1990
  • Visiting Investigator, Sloan-Kettering Institute for Cancer Research, 1992
  • Professor, Tohoku University, 1997

Aims and scope of our research

  • The focus of our research is the elucidation of regulatory functions of immunoglobulin (Ig)-like receptors, including Fc receptors (FcR) and paired Ig-like receptors (PIR), natural killer cell-surface receptors, and other immunoreceptors with the phospho-tyrosine-based ITAM/ITIM modules. Our research programs include development of novel gene-targeted mice, generation of novel animal models for human diseases, dissection of relationship between immunoreceptors and diseases, fishing out novel receptor or subunit molecules involved in immunoregulation. Particularly, in our Network Medicine G-COE program, we will make efforts to develop novel and innovative therapeutic strategies to immune, metabolic, and vascular diseases and malignancies by identifying novel molecular links among these disorders. In addition to our focusing on research and discovery, we are also dedicated to quality education for young students, graduate students and post-doctoral fellows.


  • tostakai[atmark]


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Tohoku University Global COE for Conquest of Signal Transduction Diseases with Network Medicine